ETC-1002

Product Name: ETC-1002
CAS No.: 738606-46-7
Chemical Name: ETC-1002
Synonyms: Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bempedoic Acid, API;ETC-1002 (ESP 55016)
CBNumber: CB73034632
Molecular Formula: C19H36O5
Formula Weight: 344.49
MOL File: 738606-46-7.mol

More

Less

ETC-1002 Property

Melting point:: 87 - 92°C
Boiling point:: 506.5±35.0 °C(Predicted)
Density: 1.045±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 4.55±0.45(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChIKey: HYHMLYSLQUKXKP-UHFFFAOYSA-N
SMILES: C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 26409
Product name: ETC-1002
Packaging: 25mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 26409
Product name: ETC-1002
Packaging: 50mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 26409
Product name: ETC-1002
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26409
Product name: ETC-1002
Packaging: 10mg
Price: $50
Updated: 2024/03/01

TRC

Product number: B119700
Product name: BempedoicAcid
Packaging: 250mg
Price: $605
Updated: 2021/12/16

More

Less

ETC-1002 Chemical Properties,Usage,Production

Description

Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.

Description

ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (K_i = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe^-/-/Ampkβ1^-/- (DKO) mice.

Uses

ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

Definition

ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.

ETC-1002 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ETC-1002 Suppliers

China 209 India 26 United States 11 Global 246

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 1091
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from ETC-1002 manufacturers

PNP Biotech Co. Ltd

Product: Bempedoic Acid 738606-46-7
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-09-29

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bempedoic acid 738606-46-7
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-02

Henan Aochuang Chemical Co.,Ltd.

Product: Bempedoic acid (ETC-1002) 738606-46-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

738606-46-7, ETC-1002Related Search:

Bempedoic Acid Impurity 1-d4 Bempedoic Acid-d4

ETC-1002

Bempedoic Acid

ETC-1002 (ESP 55016)

ESP 55016

ETC-1002(BEMPEDOIC ACID)

CS-1544

Bempedoic Acid(ETC-1002

Bempedoate

ESP-55016; ESP55016; ESP 55016; ETC-1002; ETC 1002; ETC1002; BEMPEDOATE; BEMPEDOIC ACID

BEMPEDOIC ACID;ESP-55016;SGI-7079

Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-

Bempdic acid

Bempedoic acid In-House

8-hydroxy-2,2,14,14-tetramethylpentadecanedioicaci

Bempedoic Acid, API

Bempedoic

738606-46-7

API